老年女性骨密度与左心室肥厚的相关性

Association of bone mineral density with left ventricular mass index in the elderly women

背景:老年女性心血管事件发生率增加与骨量减少相关,左心室肥厚是明确的心血管事件独立危险因素,这两者在发病机制上可能相关。目的:探讨老年女性骨量与左心室质量指数的相关关系。方法:选取老年女性受试者157例,按照骨密度分组,分为骨量正常组、骨量减少和骨质疏松组。进行病史询问及临床检查,测定生化指标,完成股骨骨密度和腰椎骨密度测定,进行超声心动图检查,计算得出左室质量指数。进行单因素方差分析和多因素多元线性回归分析。结果与结论:随着骨量减少,左室质量指数逐渐增大,左心室肥厚发生率上升,差异有显著性意义(P<0.05)。以左室质量指数为因变量,多元线性回归分析显示,年龄、收缩压、高血压病程、腰椎骨密度或股骨骨密度与左室质量指数独立相关。结果提示在老年女性人群中,骨密度可能是影响左室质量指数的独立危险因素。

BACKGROUND： There is an association between cardiovascular disease and osteoporosis in elderly women. Left ventricular hypertrophy is the independent determining factor for cardiovascular events. Osteoporosis and left ventricular hypertrophy might be linked by some common pathological mechanismsOBJECTIVE： To investigate the association between bone mineral density and left ventricular mass index in the elderly women. METHODS： Totally 157 elderly women were enrolled and divided into a normal group, bone loss group and osteoporosis group according to the bone mineral density. Bone mineral density, echocardiogrephy measurements as well as the measurements of blood biochemical markers were analyzed. Left ventricular mass index was obtained by echocardiography. One-way analysis of variation and multiple stepwise linear regression analyses were performed for identifying determinants of left ventricular mass index. RESULTS AND CONCLUSION： With the increasing of bone loss, left ventricular mass index and prevalence of left ventricular hypertrophy were increased significantly （P 〈 0.05）. Multiple stepwise linear regression analyses demonstrated that the lumbar and femoral bone mineral density was correlated with left ventricular mass index, and the association remained statistically significant after adjusting for age, systolic blood pressure; fasting blood glucose, serum creatinine and blood lipid. Age, systolic blood pressure, and lumbar or femoral bone mineral density were independent predictors of left ventricular mass index. In the elderly women, bone mineral density may be an independent determining factor for left ventricular mass index.