摘要
MicroRNAs （miRNAs） are a class of short, single-stranded, noncoding RNAs that modulate avariety of biological functions as negative regulators gene expression. Post-transcriptional regulation of by miRNAs is crucial in many aspects including cell proliferation and death. They play important regulatory roles in endothelial cell function, which are significant for the treatment of endothelial dysfunction and related metabolic disorders. This review summarizes current insights into the functions of miRNAs, focusing specifically on the regulation of endothelial function.
MicroRNAs （miRNAs） are a class of short, single-stranded, noncoding RNAs that modulate avariety of biological functions as negative regulators gene expression. Post-transcriptional regulation of by miRNAs is crucial in many aspects including cell proliferation and death. They play important regulatory roles in endothelial cell function, which are significant for the treatment of endothelial dysfunction and related metabolic disorders. This review summarizes current insights into the functions of miRNAs, focusing specifically on the regulation of endothelial function.
基金
The project was supported by grants from the National Natural Science Foundation, China （No.81173367 and No. 81273890）.
