小儿弱视视觉皮层的BOLD-fMRI研究进展

Study of visual cortex of children amblyopia with blood oxygen level dependent-functional magnetic resonance imaging

血氧饱和度水平依赖性功能性核磁共振(BOLD-fMRI)利用血液中脱氧血红蛋白这一内源性顺磁物质作为对比剂,获得大脑皮层血管内MRI信号变化,从而得到大脑激活区域的图像,由于其定位精确、直观,属无创性检查,应用领域广泛,为弱视神经发生机制、眼优势柱、视觉运动觉及色觉等方面的研究提供了可视和客观的依据。

Blood oxygen level dependence-functional magnetic resonance imaging （BOLD-fMRI） utilizing the endogenous paramagnetic material- deoxygenated hemoglobin as a contrast agent gains signal changes of MRI in cortical intravascular and obtains images of the active area. Due to accurate location, intuitive and noninvasive, BOLD-fMRI is applied widely and provides objective evidence for amblyopia neurogenesis mechanism, ocular dominance column, motion perception and color vision.