雷珠单抗玻璃体腔内注射联合激光光凝治疗黄斑囊样水肿

Intravitreal lucentis combined laser photocoagulation treatment on macular edema

目的:观察雷珠单抗玻璃体腔内注射联合激光光凝治疗黄斑囊样水肿的疗效。方法:2011-12/2013-01在我科确诊的黄斑囊样水肿患者98例136眼,其中单眼患者40例,双眼患者48例,随机选48例双眼患者中任一眼及40例单眼患者中20眼共68眼为玻璃体腔内注药联合光凝治疗组(简称联合组),另68眼为单纯光凝治疗组(简称单纯光凝组),两组黄斑水肿无显著性差异。联合组先行雷珠单抗玻璃体腔内注射,1wk后再行标准的黄斑区格栅状光凝;单纯光凝组行标准的黄斑区格栅状光凝治疗,对比分析治疗前后视力、眼底及眼底荧光血管造影(FFA)的变化。结果:联合组视力提高51眼(75.0%),视力不变10眼(14.7%),视力下降7眼(10.3%)。水肿吸收59眼(86.8%),水肿未退9眼(13.2%);单纯光凝组视力提高12眼(17.6%),视力不变42眼(61.8%),视力下降14眼(20.6%)。水肿吸收21眼(30.9%),水肿未退47眼(69.1%),经统计学分析,联合组较单纯光凝组视力提高多,黄斑水肿吸收快(P<0.05)。结论:玻璃体腔内注射雷珠单抗联合激光光凝治疗可促进黄斑囊样水肿的吸收,提高患者视力。

AIM：To investigate the efficacy of intravitreal lucentis combined laser photocoagulation treatment on macular edema. METHODS： Ninety eight patients （136 eyes） with macular edema diagnosed by ocular-fundus examination, fundus fluorescein angiography （FFA）. Sixty-eight eyes of them were treated with intravitreal lucentis combined laser photocoagulation and sixty-eight eyes only laser photocoagulation. The follow-up time was 1 month, 3, 6 months. Visual acuity and FFA were measured. RESULTS： Among patients with intravitreal lucentis combined laser photocoagulation, visual acuity in 51 eyes （75.0%） was improved in 2 lines or more and 10 eyes 14.7% ） remained no change, 7 eyes（ 10.3% ） deceresed. Edema in 59 eyes （86. 8%） reduced after treament. Among patients with laser photocoagulation, visual acuityin 12 eyes （17.6%） was improved in 2 lines or more and 42 eyes 61.8%） remained no change, 14 eyes（20.6%） deceresed. Edema in 21 eyes （30. 9%） reduced after treatment. CONCLUSION： The result of intravitreal lucentis acetonide combined laser photocoagulation treatment for macular edemae is better than those of only using laser photocoagulation.