促动力药在功能性消化不良中的应用

Prokinetic Agents in Functional Dyspepsia

促动力药主要包括多巴胺D2受体拮抗剂、5-羟色胺受体激动剂、阿片受体激动剂、胃动素受体激动剂等,临床上广泛应用于功能性消化不良(FD)患者的治疗。该类药物可通过增强和协调胃肠运动、促进胃排空和肠道转运而改善消化不良症状。本文对FD患者常见的胃动力变化以及常用促动力药对FD的疗效、作用机制和不良反应作一概述。

Prokinetic agents, including dopamine D2 receptor antagonists, serotonin receptor agonists, opioid receptor agonists and motilin receptor agonists, are widely prescribed in patients with functional dyspepsia （FD） in clinical practice for improving the dyspeptic symptoms by enhancing and coordinating the gastrointestinal motility and stimulating gastric emptying and intestinal transit. In this article, the most common gastric motility disorders and the efficacies, mechanisms and adverse reactions of prokinetic agents frequently used in the treatment of FD were briefly summarized.