吡咯列酮对家兔血脂水平的影响及安全性评估

Effection on lipid and drug safety of pioglitazone in rabbits

目的:探讨吡咯列酮对家兔血脂水平的影响及安全性。方法:将36只新西兰白兔随机分为正常对照组、高胆固醇饮食组、高胆固醇饮食加吡咯列酮组,喂养8周后处死,取兔血清测定血脂、肝功及肾功。结果:高胆固醇饮食组及高胆固醇饮食加吡咯列酮组TC、TG、LDL-C均高于正常对照组,HDL-C水平均低于正常对照组(P<0.05);高胆固醇饮食加吡咯列酮组TG水平低于高胆固醇饮食组,HDL-C高于高胆固醇饮食组(P<0.05)。三组间血清谷丙转氨酶、肌酐水平比较均无显著性差异(P<0.05)。结论:吡格列酮可降低高脂饮食兔血清TG水平,升高高脂饮食兔血清HDL-C水平,对肝肾功能无影响。

Objective： To investigate the effection on lipid and drug safety of pioglitazone in rabbits. Meth- ods： 36 healthy WHHL rabbits were randomly divided into 3 groups： normal control group, high-cholesterol diet group, high-cholesterol diet with pioglitazone group. All animals were feeding for 8 weeks and sacrificed. At the end of the treatment, took rabbits blood to measure lipids, hepatic function and renal function respectively. Results：Ser- um TC, TG, LDL-C in high-cholesterol diet group, high-cholesterol diet with pioglitazone group were higher than in normal control group, HDL-C was lower than normal control group（P〈0.05）. In high-cholesterol diet with pioglita- zone group , serum TG was lower comparision to high-cholesterol diet group, HDL-C was higher（P〈0.05）. A- mong the 3 groups, there is no significant difference about serum ALT and Cr （P〈0.05）. Conclusion： Preventive taking pioglitazone can reduce the elevated TG level and increaseHDL-C level in high-fat diet rabbits, there is no im- pact on hepatic and renal function.