抑郁情绪对OSAHS患者血清ICAM-1,NO表达的影响

Effect of Depression on Express Level of ICAM-1,NO in Serum of the Patient with OSAHS

目的探讨抑郁情绪对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者炎症反应及内皮功能的影响。方法对初次确诊OSAHS的56例男性患者行抑郁自评量表调查,45例患者入选本实验,其中OSAHS组25例、OSAHS并抑郁组20例,选取健康志愿者20例为健康对照组。检测各组血清细胞间粘附分子-1(ICAM-1)、NO的表达水平并将其进行组间比较。OSAHS组、OSAHS并抑郁组抑郁自评得分分别与血清ICAM-1,NO表达水平及PSG检测结果行相关性分析。结果血清ICAM-1的表达水平在OSAHS组、OSAHS并抑郁组较正常对照组明显升高,差异有统计学意义(P<0.05)。在OSAHS并抑郁较OSAHS组也有显著升高(P<0.05),血清NO表达水平在OSAHS组、OSAHS并抑郁组较正常对照组明显减低(P<0.05),OSAHS并抑郁组较OSAHS组中也有降低趋势,但差异无显著性(P>0.05)。抑郁自评量表得分与血清ICAM-1呈正相关(r=0.364,P<0.05),与最低血氧饱和度LSpO_2呈负相关(r=-0.412,P<0.05),与AHI,BMI,NO无相关性。结论抑郁情绪可能加重OSAHS患者的血清炎症水平并加重患者内皮功能紊乱。

Objective To explore the effect of depression on the inflammation and endothelium function in patients with obstruc- tive sleep apnea hyponea syndrome（ OSAHS）. Methods Filly-six male patients who were diagnosed as OSAHS for the first time were select- ed. Self-rating depression scale（SDS） was used to evaluate the mental condition of patients. At last there were 45 patients involved in the study. All the 45 patients were divided into two groups ： OSAHS group （ 25 cases ） OSAHS and depression group （ 20 cases ）. Twenty healthy volunteers were chosen as control group. Test the ICAM-I anti NO levels in the sermn of the three groups. Correlation analysis was made be- tween the SDS scores and the levels of inflammation tactors as well as the indexes of PSG results. Results The serum levels of ICAM-1 were significantly higher in the OSAHS and OSAHS with depression groups than in the control group. The tilt＇terence between OSAHS group and OSAHS with depression group was also significanh The senm2 levels of NO were signiticantly lower in the OSAHS and OSAHS with depression groups than in the control group. But there was no sigdticant difference between OSAHS group and OSAHS with depression group. The SDS scores had the positive correlation with ICAM-1 but the negative correlation with the lowest saturation（ LSpO, ）. SDS scores had no correlation with AHI,BMI and the levels of NO. Conclusion The mood of depression may aggravate the inflammation reaction and exacerbate the dys- function of the endothelium.