核分裂像、Ki-67的表达与低级别宫颈上皮内瘤变发展的关系

Relationship between the Expression of Ki-67,Nuclear Mitotic Figure and the Development of Low Grade Cervical Intraepithelial Neoplasia

目的探讨核分裂像、Ki-67表达指数在预测宫颈低级别上皮内瘤变发展中的作用．方法选择潍坊市妇幼保健院自2009年-20l1年间病例资料完整经病理诊断确定为低级别上皮内瘤变（CINI）患者400例。采用免疫组织化学sP法检测CINI中Kj-67的表达。镜下观察细胞核分裂像数目，随访5年观察疾病的进展情况。结果核分裂像〉2／5HPF患者发展为高级别上皮内痛变的比率为3l％．核分裂像〈2／5HPF患者发展为高级别上皮内瘤变的比率为4％，两者比较差异有统计学意义（P〈0．05）。高表达Ki击7的CINI患者发展为高级别上皮内瘤变的比率为20．8％，低表达Ki-67的CINl患者发展为高级别上皮内瘤变的比率为6．4％，两者比较差异有统计学意义（P〈0．05）。结论核分裂像较高、Ki-67指数较高的CINI患者发展为高级别上皮内瘤变的可能性较大.

Objective To investigate the rule of expression of Ki-67 and nuclear mitotic figure in predicting the development of low grade cervical intraepithelial neoplasia. Methods Four huudred eases wilh complete clinical data selected from the maternal and Child Heahh Hospital of Weitang city from 2009 to 2011. All cases were confirmed by pathology identification as low grade intraepithelial neoplasia （ CIN I ） Expression of Ki-67 was detected with immunohistochemieal SP method. It observed the nuclear mitotie figure under the miero- scope. All eases were followed up for 5 years. Results 31% Patients with 〉 2/SHPF mitotic figure developed into high grade intraepithelial neoplasia. Whereas,4% patients with 〈 2/5HPF mitotie figure developed into high grade intraepithelial neoplasia. Both were signifieantly dif- ferent（ P 〈 0.05）. 20.8% patients with high expression of Ki-67 developed into high grade intraepithelial neoplasia. However low expression were 6.4%. There were significant difference（ P 〈 0.05 ）. Conclusion The higher expression of Ki-67 or the more nuclear mitotic figure CIN I ,more likely developed into high grade intraepithelial neoplasia.