摘要
目的了解男男性行为人群(MSM)艾滋病病毒(HIV)感染者及病人中,合并人乳头状瘤病毒(HPV)感染及其亚型分布状况。方法采用杂交捕获法,分别对MSM人群的HIV感染者及病人(观察组)和男性尖锐湿疣患者(对照组)进行HPV分型检测。结果在观察组91例患者中,合并HPV阳性检出率为73.63%(67/91),共检出15个HPV亚型,其中高危亚型11个(16、18、31、33、45、52、56、59、66、68、73型),低危亚型4个(6、11、42、43型)。单一亚型感染占31.34%(21/67),多重亚型感染占68.66%(46/67)。高危亚型感染占44.78%(30/67),低危亚型感染占55.22%(37/67)。观察组病例的多重亚型HPV感染率(χ2=30.6474,P<0.000 1)和高危亚型HPV感染率(χ2=22.3210,P<0.000 1)都高于对照组,差异有统计学意义。结论在MSM人群中,HIV合并HPV感染呈较高流行状态,HIV感染者罹患肛门生殖器肿瘤的风险增加,提示加强HIV感染者HPV感染的防治有重要意义。
Objective To explore the status of HPV infection and the distribution of HPV subtypes among HIV positive MSM. Methods The detections of HPV-subtypes targeting HIV positive MSM (trial group) and the male patients with condyloma acuminatum (control group) were performed with hybrid capture approach. Results Of the 91 patients in the trial group, 73.63% (67/91) were HPV positive, and 15 subtypes of HPV including 11 high- risk subtypes (16, 18, 31, 33, 45, 52, 56, 59, 66, 68 and 73) and 4 low-risk subtypes (6, 11, 42 and 43) were identified. Single HPV-subtype infections accounted for 31.34 % (21/67), multiple HPV-subtype infections accounted for 68.66 % (46/67), high-risk HPV-subtype infections accounted for 44.8 % (30/67) and low-risk HPV-subtype infections accounted for 55.2% (37/67). Compared with the control group, the multiple HPV-subtype infec- tions and high-risk HPV-subtype infections in the trial group were significantly higher. Conclusion A high prevalence of HPV and HIV co-infections were found among MSM population, and the HIV infected people were at a higher risk for the anus and genital tumors. The study indicated that it is important to strengthen prevention and control focusing on HPV infection among MSM.
出处
《中国艾滋病性病》
CAS
2013年第4期239-240,247,共3页
Chinese Journal of Aids & STD
基金
湖北武汉中盖艾滋病防治项目(No:wh12c13)~~