复方浙贝颗粒对Graves病患者甲状腺激素及自身抗体的影响

The influence of Compound Thunbery Fritillary Bulb on thyroid hormone and autoantibodies of patients with Graves' disease

目的观察复方浙贝颗粒对Graves(GD)病患者甲状腺激素及自身抗体的影响。方法将82例Graves病患者随机分为治疗组(复方浙贝颗粒联合甲巯咪唑)和对照组(甲巯咪唑),观察两组连续用药12个月,治疗前后甲状腺激素、甲状腺相关抗体、停药后复发率等的变化。结果治疗组与对照组治疗均可使GD患者血清FT3、FT4、TRAb、TPOAb水平和阳性率下降,治疗组(3.02±1.01,1.34±0.32,3.28±2.21,12.64±7.17)较对照组(4.07±0.85,2.46±0.23,9.57±3.25,36.36±8.53),下降更为显著(P<0.01),停药后随访1年,治疗组复发率(14.29%)与对照组(35%)相比(P<0.05)。结论复方浙贝颗粒可以降低Graves患者自身抗体水平,促进甲状腺机能恢复,对Graves患者的异常免疫反应有一定的调节作用。

【Objective】 To observe the Compound Thunbery Fritillary Bulb（CTFB） on Graves’ disease（GD） thyroid hormone and the influence of auto antibodies.【Methods】82 patients with Graves disease random divided into treatment group（CTFB grain joint methimazole） and control group（methimazole）,observation two groups of continuous administration 12 months,before and after the treatment of thyroid hormones,thyroid related antibody,recurrence rate after discontinuation of the change.【Resluts】The treatment group and control group treatment all can make GD patients serum FT3、FT4、 TRAb、TPOAb level and positive rate decline,the treatment group（3.02 ±1.01,1.34±0.32,3.28±2.21,12.64 ±7.17） than control group（4.07±0.85,2.46±0.23,9.57±3.25,36.36±8.53）,more significant decline（P ＆lt; 0.01）,after discontinuation of the patients were followed up for one year,the treatment group（14.29%） and control group（35%）,compared to decrease the recurrence rate（P ＆lt; 0.05）.【Conclusion】The compound prescription CTFB particle can reduce the patient’s own Graves antibody level,promote the thyroid function recovery,Graves for patients with abnormal immune response has certain regulatory role.