D-二聚体及超敏C反应蛋白对创伤后颅内进展性出血性损伤的诊断价值

Diagnostic value of D-dimer and high-sensitivity C-reactive protein on progressive hemorrhagic brain injury

目的探讨血浆D-二聚体及血清超敏C反应蛋白表达的高低与脑损伤后进展性出血性损伤(PHI)发生的关系。方法以新入院180例颅脑外伤病例为研究对象,分别检测单纯性闭合性颅脑外伤患者血浆D-二聚体浓度及血清中超敏C反应蛋白(hs-CRP)的表达情况,并与87例对照组进行比较。受试者工作特征(ROC)曲线计算血浆D-二聚体及hs-CRP浓度与PHI发生的关系。结果脑外伤患者中PHI组的D-二聚体的平均浓度为6.49±3.45mg/L,非PHI组D-二聚体的平均浓度为4.16±3.15mg/L,两组间差异有统计学意义;且D-二聚体及hs-CRP的值与脑外伤患者的预后评分成正相关。结论检测脑外伤患者血中的D-二聚体及hs-CRP的浓度表达有助于预测或早期诊断PHI的发生。

Objective To explore the diagnostic value of serum D-dimer and high-sensitivity C- reactive protein on progressive hemorrhagic injury （PHI）. Methods The expression of serum D- dimer and high-sensitivity C-reactive protein between 180 patients with traumatic brain injury and 87 patients in control group were compared respectively. And the diagnostic powers of serum D-dimer and high-sensitivity C-reactive protein were estimated by receiver operating characteristic （ROC）curve analysis. Results The average concentration of D-dimer of PHI group in patients with brain injury was （6.49 ± 3.45 ） rag/L, while the concentration of NPHI group was （4.16 ± 3.15 ） mg/L,and there were significant differences in different group. Besides, increased serum high-sensitivity C-reactive protein was observed in PHI group with brain injury. Conclusions The expression levels of serum D- dimer and high-sensitivity C-reactive protein are related to PHI. And both of them may serve as a potential marker to the progressive hemorrhagic brain injury.