甲状腺自身抗体以及促甲状腺素与流产的关系探究

Relationship between Throid Antoantibody and Throid Stimulating Hormone and Abortion

[目的]探讨甲状腺自身抗体和促甲状腺素(thyroid stimulating hormone,TSH)在预测流产中的价值。[方法]选择我院109例孕前或早孕期患者,对其进行常规甲状腺自身抗体和TSH筛查,并持续进行跟踪回访,对流产患者和继续妊娠的患者做好分别记录统计,从而对甲状腺自身抗体和TSH引起流产的情况进行分析比较。[结果]甲状腺自身抗体阳性的患者,发生流产的概率为64.71%,TSH≥2.5mIU.L-1的亚型临床甲状腺功能减退的患者,发生流产的概率为46.15%,差异无统计学意义(P>0.05)。而TSH水平≥2.5mIU.L-1并伴有自身抗体阳性的患者,发生流产的概率为100%;TSH水平<2.5mIU.L-1并伴有自身抗体阴性的患者,发生流产的概率约为4.86%;单纯血清TSH水平≥2.5mIU.L-1的患者,发生流产的概率为22.22%;单纯甲状腺自身抗体阳性的患者,发生流产的概率为53.86%,差异有统计学意义(P<0.05)。[结论]甲状腺自身抗体及TSH在预测流产方面均具有着较高的价值,而相比较而言,甲状腺自身抗体具有着更多的预测价值,但二者联合预测,会具有更大价值,值得在临床上广泛推广经验。

[Objective] To explore the value of thyrod antoantibody and thyrod stimulating hormone（TSH） in prospecting abortion. [Method] Select 109 cases of pre-pregancy and early pregnancy, screen out their routine thyroid antoantibody and TSH, and make continual follow-up, make record and statistics of the abortion and continual pregnancy, and make ananlysis and comparison on abortion caused by thyroid antoantibody and TSH.[Result]For the positive thyroid antoautibody patients, the abortion rate is 64.71%; for those subtype clinical hypothyroidism with TSH ≥2.5mIU.L ^-1,the abortion rate is 46.15%, the differnece between them has no statistical meaning; while for those positive antoantibody cases with TSH ≥ 2.5mIU.L ^-1, the rate is 100%; for those negative antoantibody cases with TSH〈2.5mIU.L ^-1,the rate 4.86%; for those with pure serum TSH ≥2.5mIU.L ^-1,the rate 22.22%; for those with positive thyroid antobody, the rate 53.86%, with difference of statistical meaning. IConclusion]The thyroid antoantibody and TSH have high value in prospecting abortion, comparatively, the antoantibody has more predictive value, but conabination of both has still more value, worthy clinical promotion.