抗幽门螺杆菌治疗对2型糖尿病患者炎症因子的影响

Down-regulation inflammation.factor by treatment of anti-Helicobacter pylori in patients with type 2 diabetes mellitus

目的探讨抗幽门螺杆菌治疗对2型糖尿病患者炎症因子的影响。方法将120例2型糖尿病合并幽门螺杆菌感染患者随机分为对照组和治疗组，治疗组行抗幽门螺杆菌治疗。患者治疗3个月后再次评价幽门螺杆菌感染情况；均在治疗前及治疗3个月后检测患者血糖、糖化血红蛋白（HbAlc）、血脂以及超敏c反应蛋白（hs-CRP）、血清白细胞介素（IL）-6、IL-8、肿瘤坏死因子（TNF）-α水平。结果治疗组幽门螺杆菌转阴率明显高于对照组；治疗前及治疗3个月后两组患者空腹及餐后2小时血糖、HbAlc、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-c）和高密度脂蛋白胆固醇（HDL-C）水平比较差异无统计学意义（P〉0．05）；治疗3个月后，治疗组hs-CRP、IL-6、IL-8和TNF．仅均较治疗前降低且低于对照组（P〈0．05）。结论有效的抗幽门螺杆菌治疗可以降低2型糖尿病患者体内炎症因子水平，减轻炎症反应。

Objective To investigate effects of anti-Helicobacter pylori on inflammation factor in patients with type 2 diabetes mellitus. Methods 120 type 2 diabetes mellitus patients with Helicobacter pylori infection were randomly divided into control group and treatment group with 60 patients in each group. Patients in treatment group were administered by anti-Helicobacter pylori. Helicobacter pylori infec- tion were detected in all patients at 3 months after treatment, and blood levels of glucose, glycosylated he- moglobin （ HbA1 c ）, blood lipids, high sensitivity C reactive protein （ hs-CRP）, interleukin （IL） -6, IL-8 and tumor necrosis factor（TNF）-α were detected before and at 3 months after treatment. Results Rate nega- tive of Helicobacter pylori infection were higher in treatment group than in control group at 3 months after treatment. There were no differences on blood levels of fasting glucose,2-hour postprandial blood glucose, HbA1 c, total cholesterol, triglyeride, low density lipoprotein cholesterol and high density lipoprotein choles- terol between two groups before and at 3 months after treatment （P 〉 0. 05 ）. In treatment group, blood lev- els of hs-CRP, IL-6, IL-8 and TNF-α at 3 months after treatment were lower than those before treatment and were lower than those in control group（P 〈 0.05 respectively）. Conclusion Treatment of anti-Heli- cobacter pylori can down-regulate blood levels of inflammation factor in patients with type 2 diabetes melli- tus.