浅谈坎地沙坦的合成方法

Discuss the Synthesis of Candesartan Method

高血压是导致心、脑血管疾患的一个主要危险因素,对人体副作用小、依赖性低的压药物越来越受到人们亲睐,血管紧张素Ⅱ受体AT1拮抗剂以其副作用小,同时具有靶器官(血管、肾脏和心脏等)保护作用,将成为今后抗高血压药物市场中的竞争主角。坎地沙坦是这一类拮抗剂的典型代表药物,本文总结近十年经典的合成坎地沙坦的方法,着重诉述了各个合成路线中关键中间体的优缺点和工业化生产过程中的注意事项。

Hypertension is a major risk factor leading to cardiovascular and cerebrovascular disorders , more and more people pro - gaze on the human side effects and dependence of low pressure drugs , angiotensin Ⅱreceptor AT1 antagonist its side effects , but also has the protective effect of the target organs （ blood vessels, kidneys and heart , etc. ） , will be the protagonist of the competition in the anti hypertensive drug market in the future. Candesartan is a typical representative of this class of antagonists drugs This paper summarizes the synthesis candesartan in nearly a decade the classic method , the attention of the key intermediate of the advantages and disadvantages of each synthetic route and industrialized production process focuses v. state matters.