RELMβ在慢性阻塞性肺疾病患者肺组织中的表达

The expression of RELMβ in lungs from patients with chronic obstructive pulmonary disease

目的:研究抵抗素样分子β(resistin like molecule beta,RELMβ)在慢性阻塞性肺疾病(COPD)患者肺组织中的分布及表达。方法:采集暨南大学附属第一医院因肺癌入院行肺叶切除术的19例肺组织标本,分为COPD组(10例)和对照组(9例)。采用HE染色、免疫组织化学染色及Western blot方法,检测RELMβ蛋白的表达情况。结果:COPD组患者肺组织中RELMβ的表达(2.657±0.387)明显高于肺功能正常组(0.386±0.072)(P<0.05),且与肺功能主要指标(FEV1%预计值、FEV1/FVC%)呈负相关;与吸烟指数呈正相关(P值均<0.05)。结论:RELMβ可能参与慢性阻塞性肺疾病的发病过程。

Aim： To explore the distribution and expression of Resistin like molecule beta in lungs from patients with chronic obstructive pulmonary disease （COPD）. Methods： According to the latest COPD diagnostic criteria, 19 patients with lung cancer underwent pneumonectomy were divided into COPD group （10 cases） and normal lung function group （9 cases）. Pathomorphological changes of the lung tissues were observed by routine H. E dyeing. The expression of RELMβ in the lung tissues was identified by immunohistochemistry and western blot. Results： The RELMβ protein in COPD group （ 2. 657 ± 0. 387 ） was significantly higher than that in non-COPD group（0. 386 ±0. 072） （P 〈0. 05 ）. The correlation analysis showed that RELMβ was negatively correlated with FEV1/FVC% and FEV1/pre%, but positively correlated with smoking index（P 〈0. 05 ）. Conclusion：The results suggest that RELMβ may participate and promote in the occurrence and development of chronic obstructive pulmonary disease.