龙胆苦甙对CCl_4、扑热息痛毒性的保护作用

THE PROTECTIVE EFFECTS OF GENTIOPICROSIDE ON MICE INTOXICATED BY CCI_4 AND ACETAMINOPHEN

龙胆苦甙在CCl_4染毒前后给药及染毒前给药均可显著降低小鼠的死亡率,且能明显提高LD_(50)。CCl_4组的LD_(50)为1222mg/kg,CCl_4染毒前后给药纽,染毒前给药组的LD_(50)分别为1775mg/kg,1610mg/kg。仅CCl_4染毒后给药对小鼠死亡率及LD_(50)无明显影响。龙胆苦甙预先给药可显著降低扑热息痛处置的小鼠死亡率。

Gentiopicroside (GP) significantly reduced mice mortality given both before/after and before intoxication of CCl_4. In the way, GP also apparently raise LD_(50) of CCl_4. The LD_(50) of CCl_4 control is 1222mg/kg, and the LD_(50) of GP treated both before/after and before intoxication of CCl_4 are 1775mg/kg and 1610mg/kg respectively. The effect of GP treated after intoxication of CCl_4 is not obvious. GP also signgicently reduced mice mortality given before the intoxication of acetaminophen.