清胰汤在急性胰腺炎患者中的临床疗效分析

Clinical analysis of Qingyi Decoction in the treatment of patients with acute pancreatitis

目的探讨清胰汤在急性胰腺炎患者中的临床疗效。方法本次研究选择的对象共128例,均为2012年1～10月湖北省十堰市红十字医院收治的急性胰腺炎患者,根据入院顺序分为观察组和对照组,各64例。对照组给予常规西药治疗,观察组在此基础上给予清胰汤加减治疗。对比两组疗效、症状体征改善时间及炎症因子水平的变化。结果观察组临床治疗总有效率(93.75%)明显高于对照组(79.69%),差异有统计学意义(P<0.05);观察组全身炎症反应、肠道功能恢复时间、禁食时间及APACHEⅡ评分均明显优于对照组,差异均有统计学意义(均P<0.05);两组患者治疗后白介素8(IL-8)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)水平均明显下降(均P<0.05),白介素10(IL-10)水平较治疗前升高(P<0.05);观察组下降及升高趋势均较对照组更早、更明显(P<0.05)。结论清胰汤治疗能明显改善急性胰腺炎患者的炎症反应,改善脏器微循环,较常规西药治疗病程明显缩短,治愈率高,值得推广应用。

Objective To explore the clinical efficiency of Qingyi Decoction in the treatment of patients with acute pancreatitis, Methods The objects of the study included 128 cases, all were admitted to Shiyan City Red Cross Hospital as acute pancreatitis patients from January to October 2012. According to the order of admission, the patients were divided into treatment group and control group, with 64 cases in each group. The control group received conventional western medicine and the treatment group was given Qingyi Decoction. The symptoms and signs of impro＇~ement and changes of inflammatory factors of the two groups were compared. The result showed that the total clinical effective rate of the treatment group was 93.75%, significantly higher than 79.69% of the control group, the difference was sta- tistically significant （P 〈 0.05）; the systemic inflammatory response, intestinal function recovery time, fasting time and APACHE Ⅱ score of treatment group were significantly better than the control group, all differences were statistically significant （P 〈 0.05）. After the treatment, IL-8, TNF-α, and CRP of the treatment group were significantly decreased （P 〈 0.05）; IL-α level was higher than before treatment （P 〈 0.05）. The trend of decline and rise of the treatment group was earlier than the control group, the difference was statistically significant （P 〈 0.05）. Conclusion Qingyi Decoction can significantly improve acute pancreatitis with inflammatory response, improve organ microcirculation, and shorten the conventional course of western medicine. The cure rate with Qingyi Decoction is high and the Qingyit Decoction is worthwhile to be applied widely.