脂微球前列地尔治疗急性脑梗死合并2型糖尿病的效果观察

Observation of curative effect on Lipid Microsphere Alprostadil in acute cerebral infarction combined type 2 diabetes

目的观察脂微球前列地尔治疗急性脑梗死合并2型糖尿病的临床疗效。方法选择中南大学湘雅医院2011年8月～2012年7月收治的脑梗死合并2型糖尿病患者60例,随机分为两组,应用脂微球前列地尔加常规治疗为治疗组,常规药物治疗为对照组。比较治疗前后两组患者神经功能缺损评分(NIHSS)、Barthel指数(BI)评分、血液流变学指标及治疗有效率。结果治疗组治疗7 d后NIHSS评分为(4.50±3.11)分,BI评分为(59.78±19.6)分;治疗14 d后NIHSS评分为(3.18±2.29)分,BI评分为(70.16±20.12)分,与治疗前及同期对照组相比差异有统计学意义(P<0.05)。治疗组全血黏度、血浆黏度、红细胞刚性指数、红细胞聚集指数、纤维蛋白原治疗14 d后分别为(4.6±0.4)mPa.s,(1.91±0.32)mPa.s,(0.53±0.03)、(2.1±0.5)、(5.3±2.0)g/L,与治疗前及同期对照组比较明显改善(P<0.05);治疗组总有效率为93.3%,高于对照组(76.6%),差异有统计学意义(P<0.05)。结论脂微球前列地尔加常规治疗能有效改善急性脑梗死合并2型糖尿病的神经功能缺损及血液黏度状况,具有良好的安全性、可靠性。

Objective To observe the effect of Lipid Microsphere Alprostadil in treating acute cerebral infarction combined type 2 diabetes. Methods 60 patients with ACI combined type 2 diabetes in Xiangya Hospital of Central South University from August 2011 to July 2012 were randomly divided into two groups. The treatment group was given Lipid Microsphere Alprostadil combined with routine treatment and the control group was merely given routine treat- ment for 14 days. National institutes of health stroke scale （NIHSS）, Barthel Index （BI）, hemorheology indexes, effective ratio were measured before and after treatment respectively. Results NIHSS, BI in the treatment group reached to （4.50±3.11）, （3.18±2.29） points and （59.78±19.6）, （70.16±20.12） points after 7 and 14 days respectively, which had statistically significant differences compared with those before treatment and the control group （P 〈 0.05）. Hemorheolo- gy indexes were （4.6±0.4） mPa-s, （1.91±0.32） mPa.s, （0.53±0.03）, （2.1±0.5）, （5.3±0.0） g/L in the treatment group after 14 days treatment, the data all had statistically significant differences compared with before treatment and control group after treatment （P 〈 0.05）. Overall effective rate in the treatment group was 93.3%, which was higher than con- trol group （76.7%）, with a significant difference （P 〈 0.05）. Conclusion Lipid Microsphere Alprostadil plus routine therapy can effectively improve the nerve function of patients with acute cerebral infarction combined type 2 diabetes and decrease the blood viscosity as well. This kind of drug is of high reliability and security.