阿托伐他汀对急性肺动脉栓塞患者的保护作用

Effect of Atorvastatin on prognostic value in acute pulmonary embolism Patients

目的研究阿托伐他汀对急性肺动脉栓塞患者的保护作用。方法选取河北大学附属医院2010年10月～2012年12月确诊为急性肺动脉栓塞患者58例。根据是否应用阿托伐他汀将其分为对照组(n=32)和阿托伐他汀组(n=26),观察15 d。比较两组患者经胸超声心动图、临床症状、体征、血气分析及C-反应蛋白表达水平。结果两组临床症状及体征:呼吸困难、胸痛、心悸、颈静脉怒张、P2亢进的发生情况差异无统计学意义(P>0.05);血气分析、右心功能不全、C-反应蛋白比较差异有统计学意义(P<0.05)。15 d阿托伐他汀组死亡率及转ICU率较对照组低(P<0.05)。结论阿托伐他汀可改善急性肺动脉栓塞患者的预后,对急性肺动脉栓塞患者有保护作用。

Objective To investigate the effect of Atorvastatin on prognostic value in acute pulmonary embolism （APE） patients. Methods From October 2010 to December 2012, 58 patients confirmed acute pulmonary embolism were enrolled in the Affiliated Hospital of Hebei University. All of patients were divided into two groups： control group （n=32） and Atorvastatin group （n=26）, the time of observation were 15 d. The symptoms, signs, blood gas profiles, echocardiography results and serum of CRP level were recorded and compared. Results Between the two groups, the symptoms and signs including the incidences of dyspnea, pectoralgia, cardiopalmus, jugular vein engorgement, and P2 hyperthyroidism were not different （P 〉 0.05）. Blood gas analysis cardioventricular disfunction and serum of CRP level were different （P 〈 0.05） between the groups. Mortahy and switch to ICU in Atorvastatin group was lower than that in contol group （P 〈 0.05）. Conclusion Atorvastatin can improve the prognosis of acute pulmonary embolism patients, and protect them.