VEGF-C蛋白在肝癌组织中的表达及临床意义

Expression of VEGF-C in PHC Tissues and its Clinical Significance

目的:探讨VEGF-C在肝癌不同病变时期中的表达情况及其临床意义。方法:使用石蜡包埋组织(其中120例原发性肝癌,90例同组行手术切除的正常肝组织)构建组织微阵列,进行免疫组织化学染色,了解VEGF-C蛋白表达情况和肝癌病理临床的关系。结果:VEGF-C蛋白在肝癌组织原发病灶的表达阳性率为65%,明显高于作为对照组的正常肝组织(VEGF-C蛋白表达阳性率为5.6%,P<0.01)。而发生转移〔包括淋巴结和(或)远处转移〕的肝癌组织VEGF-C蛋白表达阳性率为76.40%,相比无转移的肝癌组织VEGF-C蛋白表达阳性率(54.84%)有统计学意义(P=0.03)。结论:VEGF-C蛋白在肝癌原发组织高表达,且与肿瘤的TNM分期、转移情况呈正相关。

Objective：To explore the expression of VEGF-C in the hepatocelluar carcinoma tissue and it is clinical significance.Methods： Use tissue microarray（TMA）（which containing 120 samples come from PHC cases,and containing 90 samples derived from normal liver tissue）,was examined by IHC（immunohistochemical） analysis,and to explore the relationship of VEGF-C expression and PHC deffience clinical series.Results： IHC results found that the positive expression rates of PHC was 65%,which was significance higher than normal liver tissue（5.6%,P0.01）.In further reaserch showed that VEGF-C expression rate of 76.40% in the correspond metastase in lymph,and VEGF-C expression in higher level in PHC primary tumor without lymphatic.Conclusions：VEGF-C expression is significantly high in PHC tumours,and in positive relationship with tumours TNM series.