依达拉奉联合纳洛酮治疗急性脑梗死的疗效及对C-反应蛋白的影响

Effect of edaravone combined with naloxone on treatment of acute cerebral infarction and its influence on C-reactive protein

目的探讨依达拉奉联合纳洛酮治疗急性脑梗死的疗效及对C-反应蛋白变化的影响。方法选择2010年1月～2012年12月在我院住院的急性脑梗死患者80例，按治疗方法不同分为对照组与治疗组，对照组38例患者采用常规方法治疗，治疗组42例患者在对照组的基础上采用依达拉奉联合纳洛酮治疗。比较两组治疗效果以及治疗前后血清C-反应蛋白水平的变化情况。结果与对照组治疗有效率（78．9％）比较，治疗组的治疗有效率（90．5％）明显增高，差异有统计学意义（P〈0．05）。与治疗前比较，两组治疗后C-反应蛋白均明显减少，差异有统计学意义（P〈0．05）。治疗后，与对照组C-反应蛋白比较，治疗组C-反应蛋白明显降低，差异有统计学意义（P〈0．05）。结论依达拉奉联合纳洛酮治疗急性脑梗死的疗效显著．可能导致血清C-反应蛋白的分泌减少，值得在临床推广。

Objective To investigate the curative effect of edaravone combined with naloxone in the treatment of acute cerebral infarction and its influence on C-reactive protein. Methods Eighty patients with acute cerebral infarction hospitalized in our hospital from January 2010 to December 2012 were divided into the control group and the treatment group according to the principle of random sampling. The 38 patients in the control group received conventional treatment and the 42 patients in the treatment group received edaravone combined with naloxone treatment. The changes of curative effect and C-reactive protein levels before and after treatment of the two groups were compared. Results The treatment effective rate （90.5%） of the treatment group was significantly higher than that （78.9%） of the control group, with statistically significant difference （P 〈 0.05）. The C-reactive protein levels of the two groups after treatment were significantly lower than those before treatment, with statistically significant difference （P 〈 0.05）. After treatment, the C-reactive protein level of the treatment group was significantly lower than that of the control group, with statistically significant difference （P 〈 0.05）. Conclusion Edaravone combined with naloxone shows significant curative effect in the treatment of acute cerebral infarction and may result in reduced secretion of serum C-reactive protein, thereby worth clinical promotion.