两种抗生素治疗小儿肺炎成本-效果分析

The cost-effectiveness analysis of two antibiotic on pneumonia for children

目的评价头孢唑啉与头孢硫脒两种抗生素治疗小儿肺炎的成本效果比，为临床治疗方案的筛选提供药物经济学依据。方法选取2011年1月～2012年1月我院收治的符合纳入标准的肺炎患儿共100例，随机分为A、B两组，A组采用头孢唑啉治疗，B组采用头孢硫脒治疗，运用成本效果分析方法评价两种给药的药物经济学效果，并进行敏感度分析。结果两组方案的有效率分别为90％、96％；病原菌清除率分别为90％、92％；两组总有效率、病原菌清除率比较均无显著差异。两组人均费用分别为2019．39元、2347．50元．两组每增加一个单位效果其增加的成本分别为22．44元、24．45元，B组费用均稍高于A组。敏感度分析显示经济学分析结果稳定。结论小儿肺炎患者使用头袍畔啉、头袍硫眯均可获得良好疗效，从药物绎济学角席分析，头孑60I琉眯更为绎济，律议优先采用。

Objective To compare the cost-effectiveness of cefazolin with cefathiamidine in treating pneumonia for children so as to provide the pharmacoeconomic evidence for drug administration and clinical decision-making.Methods One hundred children with pneumonia were selected from the hospital between January 2011 to January 2012. The patients were randomly divided into group A and group B. Patients in the group A were treated with cefazolin,and those in group B were treated with cefathiamidine. The cost-effectiveness of the two groups were compared and analyzed. Results The effective rate and pathogen clearance rate of group A were 90%,90%,and the effective rate and pathogen clearance rate of group B were 96%,92%,respectively. The effectiveness rate and pathogen clearance rate had no significant difference between two groups. The average cost in the group A and group B was 2019.39 yuan and 2347.50 yuan,respectively. The incremental cost for increase of each unit of effectiveness was 22.44 yuan and 24.45 yuan, respectively. There was significant difference between group A and group B. Sensitivity analysis revealed that the results were not sensitive to changes in the drug cost. Conclusion The unit effectiveness cost and cost in amount increase are lower in the cefazolin group than the cefathiamidine group. Therefore, the treatment with cefathiamidine is the better therapeutic scheme.