经鼻蝶入路显微镜下垂体瘤切除术临床分析

Clinical efficacy of transsphenoidal approach for microsurgical pituitary adenoma resection

目的探讨显微镜下经鼻蝶入路切除垂体瘤的临床效果。方法回顾性分析120例经鼻蝶入路切除垂体瘤患者的临床资料,分析瘤体大小、内分泌类型、肿瘤的切除范围等与临床效果的关系。结果微腺瘤的治愈率(89.8%)显著高于大腺瘤和巨大腺瘤(P<0.01)。GH腺瘤(78.1%)、ACTH腺瘤(83.3%)、混合腺瘤(80.0%)治愈率显著高于无功能腺瘤的治愈率(P<0.05)。全切和次全切患者的治愈比例(81.1%,50.0%)显著高于部分切除的患者(P<0.05)。结论经鼻蝶入路垂体瘤切除术治疗垂体瘤疗效与肿瘤的大小、功能类别、切除范围有关。

Objective To discuss the clinical efficacy of transsphenoidal approach tor microsurgery pituitary aclenoma. Methods Retrospective analysis of 120 cases treated by transsphenoidal approach on microsurgery pituitary adenoma. Relationship between size of tumors, endocrine type, tumor excision scope with clinical efficacy were analyzed. Results Cure rate of microadenoma （89.8%） was higher than macroadenoma and huge adenomas （P 〈 0.01）. Cure rate of GH adenoma （78.1%）, ACTH adenoma （83.3%）, mixed tumor of adenoma （80.0%） were higher than nonfunctioning adrenal adenoma （P 〈 0.05）. Cure rate of full-cut and subtotal resection （81.1%,50.0%） were higher than merotomy （P 〈 0.05）. Conclusion Clinical efficacy of transsphenoidal approach for microsurgery on pituitary adenoma relates to size of tumors, endocrine type, tumor excision scope.