慢性咳嗽儿童呼出气一氧化氮检测的临床意义

Clinical significance of fractional exhaled nitric oxide test in children with chronic cough

目的评估呼出气一氧化氮检测在儿童慢性咳嗽病因诊断中的价值。方法选择2011年1月-2012年9月在本院儿科呼吸专科门诊明确诊断为慢性咳嗽的患儿86例。进行FeNO检测及血IgE、肺功能、变应原皮肤点刺试验的检查。绘制ROC曲线评价FeNO对CVA的诊断价值,分析诊断CVA的最佳界值。结果诊断为CVA42例,其他病因44例。CVA组患儿FeNO、血清总IgE、过敏原阳性比例均明显高于其他病因组。应用FeNO诊断CVA的ROC曲线下面积为0.917,FeNO最佳界值为22.5 ppb,此时的灵敏度为83.5%,特异度为89.9%。结论不同病因慢性咳嗽患儿的FeNO水平存在显著性差异,FeNO对CVA的诊断具有较高的灵敏度和特异性。

Objective To explore exhaled nitric oxide detection value for chronic cough in children. Methods All of 86 patients with chronic cough identified in our hospital from January 2011 to September 2012 were involved in the study. Detected the levels of FeNO, serum IgE, lung function and allergen. Evaluated the diagnostic value of FeNO to CVA by drawing ROC curve, and analyze the best cutoff value of CVA. Results There were 42 cases included CVA and 44 cases of other causes. The levels of FeNO, blood serum IgE, allergens for CVA group children were significantly higher than the group of other causes. Diagnosed CVA from chronic cough in children,the optimal FeNO cutoff value was 22.5 ppb with a sensitivity of 83.5%,,a specificity of 89.9%. Conclusion There are significant differences between the FeNO levels of different causes of chronic cough in children. FeNO test has a high sensitivity and specificity in the diagnosis of CVA.