阿托伐他汀联合阿司匹林对脑梗死患者的疗效及预后的影响

The efficacy and prognosis of atorvastatin combination with aspirin in treatment of patients with cerebral infarction

目的探讨阿托伐他汀联合阿司匹林对脑梗死患者的疗效及预后的影响。方法选取2011年1月～2012年1月期间我院收治的急性脑梗死患者80例,分为观察组和对照组各40例。对照组给予阿司匹林,观察组则在对照组的基础上加用阿托伐他汀联合治疗,分别对两组的临床疗效情况、随访观察期复发情况及不良反应情况进行对比分析。结果观察组患者的总有效率92.5%,均明显高于对照组,两组疗效比较具有显著性差异(P<0.05)。观察组各项血脂指标的变化较对照组变化显著,具有显著性差异(P<0.05),两组患者治疗后随访12个月,观察组2例(5%)复发,对照组6例(15%)复发,两组复发率比较,具有显著性差异(P<0.05)。结论阿托伐他汀与阿司匹林联用治疗急性脑梗死可以提高其临床疗效,且不良反应少,值得推广和应用。

Objective To investigate the efficacy and prognosis of atorvastatin statins in combination with aspirin in threatment of cerebral infarction. Methods Selected 80 cases with acute cerebral infarction were divided into observation group and control group, 40 cases in each group. The control group was given aspirin treatment, the observation group on the basis of the control group with atorvastatin combination therapy, the clinical efficacy and adverse occurrence were compared and analyzed of two groups. Results The observation group of the total effective rate was 92.5%, was significantly higher than that in the control group, the two groups had a significant difference （P 〈 0.05）. Changes in serum lipids of the observation group had a significantly change than the control group, with a significant difference （P 〈 0.05）.The two groups of patients were followed for 12 months after treatment, observation group 2 patients （5%） of recurrence of the control group, 6 patients （15%） relapsed, two sets of relapse rate compared with a significant difference（P 〈 0.05）. Conclusion atorvastatin treatment of acute cerebral infarction with aspirin can improve its clinical efficacy, and adverse reactions less worthy of promotion and application.