芬太尼透皮贴剂和吗啡缓释片治疗中重度癌痛的疗效与差异比较

Comparison of effect between fentanyl transdermal system and morphine hydrochloride sustained-release tablets for cancer pain

目的比较芬太尼透皮贴和吗啡缓释片治疗中重度癌痛的临床疗效。方法回顾性分析中重度癌痛患者60例的临床资料,其中30例采用芬太尼透皮贴控制疼痛,30例采用吗啡缓释片控制疼痛治疗,比较两组疼痛控制情况。结果两组疼痛缓解程度和缓解率比较差异均不明显(P>0.05)。芬太尼组的便秘、眩晕、恶心、呕吐发病率显著低于吗啡组,而瘙痒的发病率显著高于吗啡组,两组比较差异均有统计学意义(P<0.05)。结论芬太尼透明贴能够达到和吗啡相似的镇痛效果,副作用少,值得在临床推广。

Objective To discuss effect between Fentanyl Transdermal System and Morphine Hydrochloride Sustained-release Tablets for cancer pain. Methods Retrospective analyzed clinical data of 60 cases with cancer pain, 30 cases were treated by fentanyl transdermal system, and 30 cases were treated by Morphine Hydrochloride Sustainedrelease Tablets. Clinical efficacy of two groups were compared. Results Pain control situation and remission rate of two groups had no significant difference （P 〉 0.05）. Morbidity of astriction, vertigo, nausea/throw up of Fentanyl group were lower than Morphine group（P 〈 0.05）. Conclusion Fentanyl transdermal system had the same efficacy with morphine Hydrochloride Sustained-release Tablets with less complications, worthy of application.