面部皮炎患者123例斑贴试验分析

Analysis of 123 patch tests using cosmetic component

目的:回顾分析笔者科室123例面部皮炎患者斑贴试验结果,以明确常见致敏化妆品成分及所致疾病种类。方法:对笔者科室门诊以"面部皮炎"为表现的患者进行化妆品系列变应原斑贴试验(49种变应原),按国际接触性皮炎研究组推荐标准判读结果,并对结果进行统计分析。结果:共回顾分析123例面部皮炎患者斑贴试验结果,试验阳性患者79例,阳性率64.2%;排在前3位的致敏物质主要是乳化剂和防腐剂:山梨糖醇酐倍半油酸酯(13.82%)、卡松CG(8.94%)、阿莫醇(5.69%);临床诊断中炎症性疾病,如:接触性皮炎、敏感皮肤、激素依赖性皮炎等斑贴试验阳性率80%,而色素异常性疾病,如:黑变病等阳性率约60%。结论:化妆品中山梨糖醇酐倍半油酸酯、卡松CG等是引起化妆品接触性皮炎的主要致敏成分,导致多种炎症性皮肤病和色素异常性皮肤病的发生。

Objective To elucidate the component of cosmetics leading allergy by analyzing the results of 123 patch tests in our department. Methods Patch test using cosmetics components was applied to the patients with dermatitis on the face in our department, and the result was read according to the standard of the Committee of International Contact Dermatitis. The results were then analyzed statistically. Results 123 patch tests were analyzed, 79 cases were positive with positive ratio as 64.2%.The allergic material ranking the top are Sorbitan Sesquioleate （13.82）, Fluticasone propionate CG （8.94）, AM~ alcohol （5.69）, which are mainly emulsifier agent and preservative.The diseases induced by cosmetics allergy including inflammatory diseases such as contact dermatitis, sensitive skin, with a positive ratio as 80%, and pigmented skin dieases with a positive ratio as 60%. Conclusion Emulsifier agent and preservative in the cosmetics are the major cause of cosmetics contact dermatitis, leading to many inflammatory and pigmented skin diseases.