摘要
视网膜缺血已成为致盲和引起视力损害的常见原因。青光眼、视网膜动脉阻塞及糖尿病视网膜病变等疾病均可引起视网膜缺血，建立良好的动物模型对研究此类疾病的损害机制和防治措施具有重要意义。啮齿类动物因较容易获得及与人类视网膜血液供应的相似性成为视网膜缺血疾病动物模型的首选。近年来，制作啮齿类动物视网膜缺血模型的常用方法包括升高眼压法、视神经结扎法、血管结扎法、光化学法、内皮素-1（ET-1）注射法、线栓法，每种模型均有其不同的特点。就各种常用的制作啮齿类动物视网膜缺血模型的具体操作方法及各种模型的病理变化特点进行总结，为视网膜缺血性病变基础研究的方法学提供参考。
Retinal ischemia is a common cause of blindness and visual impairment. Some eye diseases, such as glaucoma,retinal artery occlusion and diabetic retinopathy,are associated with retinal ischemia. It is very important to build an ideal animal model which can imitate human retinal ischemia disease for investigating the pathological mechanism and treatment of retinal ischemia. Rodent is a popular choice for retinal ischemia model due to its availability and the similarity to human retinal blood supply. To provide a supportive evidence of retinal ischemia research, some literature concerning rodent models is reviewed and various methods to build the model are summarized, such as elevated intraocular pressure, optic nerve ligation, ligation of vessels, photo-chemistry, endothelin- 1 injection and middle cerebral artery occlusion intraluminal suture,etc.. Here,the specific protocols,the pathological changes and molecular mechanism of each model are reviewed.
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2013年第5期513-516,共4页
Chinese Journal Of Experimental Ophthalmology
基金
北京市自然科学基金项目（7122080）
