生长抑素对重症急性胰腺炎患者血液流变学的影响

Influence of Somatostatin on Hemorrheology in Patients with Severe Acute Pancreatitis

目的探讨生长抑素对重症急性胰腺炎(severe apancreatitis,SP)患者血液流变学的影响。方法将2010年1月至2012年1月收治的重症急性胰腺炎患者132例,随机分为两组,对照组64例给予西医常规疗法,观察组68例在对照组基础上加用生长抑素。观察两组治疗后临床疗效、血液流变学指标(全血黏度、血浆黏度、红细胞压积、红细胞聚集度、三酰甘油、纤维蛋白原、红细胞聚集指数)及临床症状(腹痛缓解时间、通便时间、住院时间、胃肠功能评分)改善情况。结果观察组总有效率为95.59%,对照组为84.38%,差异有统计学意义(P<0.05)。观察组全血黏度高切(5.27,5.02)、全血黏度低切(10.21,8.25)、红细胞压积(0.51,0.40)、三酰甘油(2.55,2.21)、纤维蛋白原(2.94,2.65)、红细胞聚集指数(5.04,4.47)均低于对照组,差异有统计学意义(P<0.05)。观察组在腹痛缓解时间(1.1,2.6)、胃肠功能评分(0.46,0.97)、通便时间(15.1,35.3)、住院时间(15.4,23.2)、血淀粉酶(124.7,320.5)均低于对照组,差异有统计学意义(P<0.05)。结论生长抑素治疗急性胰腺炎疗效确切,可改善血液流变学障碍及临床症状,值得临床推广。

Objective To explore the influence of somatostatin on hemorrheology in the patients with severe pancreatitis（SP）. Methods A hundred and thirty-two cases of SP treated in our hospital from January 2010 to January 2012 were randomly divided into 2 groups. Sixty- eight cases in the control group were given the western medicine conventional therapy,while 64 case in the observation group were added with somatostatin on the base of the control group treatment. The clinical effects, hemorrheological indexes （whole blood viscosity,plasma viscosity,hematocrit, RBC aggregation degree,triacylglycerol, fibrinogen, RBC aggregation index） and the improve- ment situation of clinical symptoms （abdominal pain relief time,aperient time,length of hospital stay,gastrointestinal function score） were observed in the two groups. Results The total effective rate was 95.59% in the observation group and 84. 38% in the control group, the difference between them showing statistical significance（P 〈 0.05）. The blood viscosity high cutting,whole blood viscosity low cut, erythrocyte hematocrit,triacylglycerol,fibrinogen, RBC aggregation index in the observation groups were all lower than those in the control group with statistical differences （5.27 vs. 5.02;10.21 vs. 8.25;0.51 vs.0.40;2.55 vs. 2.21;2.94 vs. 2.65;5.04 vs. 4.47, P 〈 0.05）. Tile abdominal pain relief time, gastrointestinal function score, aperient time,length of hospital stay and blood amylase in the observation groups were all lower than those in the control group with statistical differences （1.1 vs. 2.6; 0. 46 vs. 0. 97; 15.1 vs. 35.3 ; 15.4 vs. 23.2 ; 124.7 vs. 320.5 ; P 〈 0.05）. Conclusion Somatostatin has definite effect in the treatment of acute pancreatitis and can improve the hemorrheology barriers and the clinical symptoms,which is worth clinical promotion and application.