匹伐他汀与辛伐他汀治疗老年患者高血脂的临床疗效对比

Comparative Study on Clinical Efficacies of Pitavastatin and Simvastatin for Treating Elderly Hyperlipidemia

目的比较匹伐他汀与辛伐他汀治疗老年高血脂的临床疗效。方法将老年高血脂患者114例随机分为对照组与观察组,分别采取辛伐他汀与匹伐他汀治疗,比较两组患者治疗前后血脂各项指标变化及不良反应发生情况。结果治疗后两组血脂各项指标与治疗前比较均有明显改善,且观察组各项指标变化更显著(P<0.05);两组不良反应发生率比较无统计学意义(P>0.05)。结论匹伐他汀与辛伐他汀治疗老年高血脂症均有显著疗效,且匹伐他汀临床效果优于辛伐他汀,具有明显降血脂作用,值得临床推广。

Objective To observe the clinical efficacies of pitavastatin and simvastatin for treating elderly hyperlipidemia and to explore their clinical application values. Methods A hundred and fourteen patients with elderly hyperlipidenfia treated in our hospital were ran- domly divided into the control group and the observation group. The control group was given simvastatin,while the observation group re- ceived pitavastatin. The changes of blood lipids indicators and adverse reactions before and after treatment were compared between the two groups. Results The various blood lipids indicators after treatment in the two groups were significantly improved than before treat- ment, moreover which in the observation group was more significant, the comparison between the two groups showing statistical sig- nificance （P 〈 0.05）. There was no statistical differences in the occurrence rates of adverse reactions between the two groups （P 〉 0.05）. Conclusion Pitavastatin and simvastatin have the significant effect for treating elderly hyperlipidemia, and the clinical ef- fect of pitavastatin is superior to simvastatin with obvious lipid- reducing role ,which is worth to be promoted and applied in clinic.