α-硫辛酸联合弥可保治疗糖尿病周围神经病变的疗效分析

Analysis on Clinical Effects of Alpha-Lipoic Acid Combined with Methycobal in Treatment of Diabetic Peripheral Neuropathy

目的探讨α-硫辛酸联合弥可保治疗糖尿病周围神经病变的临床疗效。方法将112例糖尿病周围神经病变患者随机分入对照组与观察组,对照组52例患者给予弥可保肌肉注射,观察组60例患者接受弥可保肌肉注射联合α-硫辛酸静脉滴注。采用总症状(TSS)评分法评估临床症状、体征,比较两组临床症状、体征及神经传导速度的改变。结果治疗后2周,观察组TSS各项评分及总分均显著低于对照组(P<0.05);观察组治疗后腓总神经和腓肠神经传导速度显著优于对照组(P<0.05)。结论α-硫辛酸联合弥可保治疗糖尿病周围神经病变,可显著改善临床症状、体征和神经传导速度,疗效优于单独使用弥可保。

Objective To explore the clinical effect of α-lipoic acid combined with methycobal in the treatment of diabetic peripheral neuropathy. Methods A hundred and twelve cases of diabetic peripheral neuropathy were randomly divided into the control group and the observation group. Fifty-two cases in the control group were given methycobal by intramuscular injection,and 60 cases in the ob- servation group received alpha-lipoic acid by intravenous drip combined with methycobal by intramuscular injection. The total symptom score （TSS） was used to evaluate the clinical symptoms and signs. The changes of clinical symptoms,signs and nerve conduction veloci- ty were compared between the two groups. Results The various items scores and the total scores of TSS scores after 2- week treatment in the observation group were significantly lower than those in the control group （P 〈 0. 05）;the nerve conduction velocities of com- mon peroneal nerve and sural nerve in the observation group were significantly superior to the control group with statistical difference （P 〈 0.05）. Conclusion α- lipoic acid combined with methycobal for treating diabetic peripheral neuropathy can greatly improve the clinical symptoms,signs and nerve conduction velocity,its effect is superior to single methycobal.