丙泊酚单用与联合芬太尼用于无痛人流术中麻醉的效果对比

Comparison of Anesthetic Effects of Single Propofol and Propofol Combined Fentanyl for Painless Induced Abortion

目的比较丙泊酚单用与联合芬太尼在无痛人流术中麻醉的效果。方法选择医院2011年1月到2012年6月行人工流产术的早孕妇女681例,分为两组,对照组325例,观察组356例。对照组患者均缓慢静脉注射丙泊酚注射液2.5 mg/kg,观察组患者先给予枸橼酸芬太尼注射液1μg/kg静脉滴注,再静脉注射丙泊酚注射液1.5 mg/kg。观察两组患者镇痛效果、术毕苏醒时间、麻醉效果以及不良反应。结果对照组镇痛总有效率为80.31%,明显低于观察组的100.00%(P<0.05);对照组术毕苏醒时间为(6.8±2.2)min,明显长于观察组的(5.4±2.1)min(P<0.05);对照组丙泊酚用量为(2.92±0.81)mg/kg,显著多于观察组的(2.22±0.42)mg/kg(P<0.05);对照组麻醉总有效率为92.62%,明显低于观察组的100.00%(P<0.05)。对照组6例患者出现轻微恶心、呕吐,观察组3例患者出现轻微恶心、呕吐等不良反应。结论丙泊酚联合芬太尼用于无痛人流术的麻醉及镇痛效果好,安全可靠,值得临床推广。

Objective To compare the anesthetic effect of single propofol and propofol combined fentanyl for painless induced abor- tion. Methods Six hundred and eighty- one early pregnant women undergoing artificial abortion in our hospital from January 2011 to June 2012 were selected and divided into two groups. The control group （325 cases） was given Propofol Injection 2.5 mg/kg by slow intravenous injection. The observation group （356 cases） was firstly given Fentanyl Citrate Injection 1 p^g/kg by intravenous drip,then Propofol Injection 1.5 mg/kg by intravenous injection. The effects of analgesia and anesthesia,postoperative awakening time and adverse reactions were observed in the two groups. Results The total effective rate of analgesia in the control group was significantly lower than that in the observation group（80.31% vs. 100.00%, P 〈 0.05）;the postoperative awakening time in the control group was signif- icantly longer than that in the observation group [（6.8±2.2）min vs. （5.4±2. 1）rain, P 〈 0.05];the propofol dosage in the control group was significantly more than that in the observation group [ （2.92 ± 0. 81 ）mg/kg vs. （2. 22 ± 0.42）mg/kg, P 〈 0.05];the anes- thetic total effective rate in the control group was significantly lower than that in the observation group （92.62% vs. 100. 00%, P 〈 0.05）. There were 6 cases of mild nausea and vomiting in the control group,while only 3 cases in the observation group. Conclusion Propo- fol combined fentanyl had the good analgesic and anesthetic effect in painless induced abortion, which is safe, reliable and worthy of being clinically promoted.