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人脑胶质瘤凋亡的原位研究 被引量：3

Apoptosis in human brain gliomas with different grades of malignancy
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摘要 目的　探讨不同恶性程度胶质瘤中凋亡的作用和意义 .方法　应用 TUNEL 技术对 38例胶质瘤的凋亡表达及其意义进行了研究 .其中低恶性胶质瘤 2 0例 ,高恶性 18例 .结果　 TUNEL 阳性细胞在各级别胶质瘤中均有表达 ,其在高分化的 ～ 级胶质瘤的阳性率 (凋亡指数 )明显低于 ～ 级胶质瘤 (2 .8± 0 .5 vs5 .6± 1.2 ,P<0 .0 1) ,其表达强度与胶质瘤的良、恶性程度明显相关 (P<0 .0 1) .结论　不同级别胶质瘤凋亡指数有明显差别 ,TU NEL法可辅助临床判断胶质瘤的良。 AIM To evaluate the actions and significance of apoptosis in different grades of gliomas. METHODS The apoptosis index (AI) in 20 cases of low grade gliomas and 18 cases of high grade gliomas was detected by techniques of terminal deoxynucleotibyl transferase (TdT) mediated dUTP nick end labeling (TUNEL). RESULTS TUNEL positive cells were present in all grades of gliomas. The low grade gliomas had a low AI compared with high grade gliomas (2.8±0.5 vs 5.6±1.2, P <0.01). The AI was significantly correlated with the glioma malignancy ( P <0.01). CONCLUSION Apoptotic index may be of value in distinguishing different malignancies of gliomas in clinical practice.
作者 陈义军 章翔 费舟 顾建文 刘卫平
机构地区 第四军医大学西京医院全军神经外科研究所
出处 《第四军医大学学报》 2000年第9期1144-1146,共3页 Journal of the Fourth Military Medical University
关键词 脑胶质瘤 细胞凋亡 原位研究 apoptosis glioma TUNEL
分类号 R739.41 [医药卫生—肿瘤]
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参考文献7

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同被引文献30

  • 1彭贵勇,袁爱力,蔡景修.荷瘤小鼠脾细胞淋转、NK和LAK活性[J].上海免疫学杂志,1994,14(4):196-198. 被引量：12
  • 2夏丽娟,韩锐.人参皂甙Rh_2体外对小鼠黑色素瘤细胞的分化诱导作用[J].药学学报,1996,31(10):742-745. 被引量：29
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  • 6[8]Hyun-Eui Kim J, SK Lee, Yong J. Gnscnoside Rh2Induces Appoptic Cell Death in Rat c6 Glionma Via Reactive Oxygen and Caspase Dependent but Bcl-XLindependent Pathway[ J ]. Life Sci, 1999,65: 33 ～ 40.
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  • 8葛迎春.人参皂甙Rh2诱注射液对核肝癌(H22)消暑免疫功能的影响[J].特产研究,2003,(3):5.
  • 9Gris P, Murphy S, Jacob JE , et al. Differential gene expression profiles in embryonic, adult-injured and adult-uninjured rat spinal cords [J]. Mol Cell Neurosci, 2003;24(3):555-567.
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第四军医大学学报
2000年 第9期

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