二苯并环庚酮的合成

Synthesis of Dibenzosuberone

用亚苄基酞经氢氧化钠水解制得2-苯乙酰基苯甲酸,经Pd/C催化氢化制得2-(2-苯乙基)苯甲酸,再在多聚磷酸作用下环合制得二苯并环庚酮,总收率约83%,纯度99.0%。

Dibenzosuberone was synthesized from benzalphthalide by hydrolysis with sodium hydroxide to give 2-phenylacetylbenzoic acid, which was subjected to hydrogenation with Pd-C to give 2- （2-phenylethyl） benzoic acid and followed by cyclization in the presence of PPA with an overall yield of 83 % and 99.0 % purity.