食管癌MAL基因变化的RNA原位杂交研究

Studies of MAL gene in human esophageal cancer by RNA in situ hybridization *

目的 观察食管癌组织及癌旁粘膜 MAL基因 m RNA的表达情况。方法 非放射性 RNA原位杂交。结果 33例配对标本中食管粘膜全部表达 MAL基因 ,而只有 8例食管癌组织表达 ,表达与否与临床参数无关。结论

Objective To observe the expression of MAL gene mRNA in esophageal cancer tissue and adjacent epithelial mucosa. Methods Non radioactive RNA in situ hybridization. Results MAL gene was expressed in all epithelia of 33 matched samples but only in 8 of esophageal cancer tissues. Differential expression between esophageal cancer tissues and adjacent epithelia was not related to clinical parameters. Conclusion Down regulation of MAL may be an important event in the development of esophageal cancer.