淋巴细胞主动免疫联合小剂量IVIG治疗URSA的初步探讨

Study on unexplained recurrent spontaneous abortion under treatment of initiative immunotherapy with lymphocytes and low-dose intravenous immunoglobulin

目的:探讨淋巴细胞主动免疫联合静脉点滴小剂量免疫球蛋白治疗复发性流产的临床疗效。方法:经临床筛查确诊为不明原因复发性流产患者72例,分为观察组(47例,采用淋巴细胞主动免疫联合静脉点滴小剂量免疫球蛋白治疗)和对照组(25例,采用淋巴细胞主动免疫治疗),观察妊娠结局。结果:妊娠成功率观察组(89.36%)高于对照组(68.00%)(P<0.05)。结论:淋巴细胞主动免疫联合静脉点滴小剂量免疫球蛋白治疗复发性流产成功率较高,有较好的应用价值。

Objective ： To investigate the effect of initiative immunotheraphy with lymphocytes and low - dose intravenous im-munoglobulin （IVIG） in women suffering from unexplained recurrent spontaneous abortion. Methods ： Seventy - two patients diagnosed as unexplained recurrent spontaneous abortion were divided into two groups： the study group （n = 47, in which women received initiative immunotherapy with lymphocytes and low - dose IVIG） and the control group （ n = 25, in which women received initiative immunotherapy only with lymphocytes）. The pregnancy outcome was evaluated. Results： The preg-nancy rate was 89.36% in the study group and only 68.00% in the control group, showing a significant difference between the two groups （ P 〈 0.05 ） . Conclusion ： Initiative immunotherapy with lymphocytes and low - dose IVIG may act as an effective and safe method for treatment of unexplained recurrent spontaneous abortion.