p-Akt与p-mTOR在大肠癌中的表达及临床意义

Expression of p-Akt and p-mTOR in Human Colon Carcinoma and Its Clinicopathological Sig-nificance

【目的】探讨p-Akt和p—mTOR蛋白表达与大肠癌临床病理特征之间的关系。【方法】采用免疫组织化学SP法检测p-Akt与p—mTOR在120例大肠癌中的表达并分析与临床病例资料的关系。【结果]p-Akt与P—mTOR在胃癌中的阳性表达率分别为75．8％（91／120）和68．3％（82／120）p-Akt与P—mTOR的高表达与大肠癌的浸润深度、临床分期、淋巴结转移、远处转移、分化程度密切相关（P〈0．05）；大肠癌组织中p-Akt与p-mTOR的表达呈显著正相关，差异有统计学意义（P〈0．01）。[结论]p—Akt与p-mTOR可能大肠癌的发生、发展中起相互协同作用，二者可能作为判断大肠癌预后及指导临床治疗的指标。

[Objective]To explore the relationship between the expression of p-Akt and p-mTOR protein and clinicopathological features in colon carcinoma. [Methods] The expression of p-Akt and p-mTOR protein in 120 cases of colorectal carcinoma was detected by immunohistochemical SP method. The relationship be- tween the expression of p-Akt and p-roTOR protein and clinical data was analyzed. [Results] The positive rates of p-Akt and p-mTOR in colon carcinoma were 75. 80//oo （91/120） and 68. 3~/oo （82/120）, respectively. High expression of p-Akt and p-mTOR was closely related to invasion depth, TNM stages, lymph node me- tastasis, distant metastasis and tumor differentiation（ P 〈20.05）. The expression of p-Akt in colon carcinoma tissues was positively correlated with the expression of p-roTOR, and there with significant difference（ P 0.01）. [Conclusion] p-Akt and p-roTOR may have the synergetic effect in the occurrence and development of colon carcinoma. Both of them may be the indicators of evaluating the prognosis and guiding clinical treatment of colon carcinoma.