基础治疗前后牙周炎患者血清及龈沟液中白细胞介素-1β和肿瘤坏死因子-α水平的变化研究

Change in levels of interleukin-1β and tumor necrosis factor-α in the serum and gingival crevicular fluid of patients with periodontitis before and after basic treatment.

目的探讨基础治疗对重度侵袭性牙周炎患者血清及龈沟液中白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)水平的影响。方法对我院2011年2月至2012年5月收治的42例牙周炎患者给予牙周基础治疗前的临床资料进行回顾性分析,并与健康人作比较。结果治疗前,观察组患者的PD、AL、BOP均明显高于对照组(P<0.01);同时,观察组患者血清及跟沟液中TNF-α、IL-1β水平均显著高于对照组(P<0.01)。经牙周基础治疗后,观察组患者PD、AL、BOP显著低于治疗前,两者比较差异有统计学意义(P均<0.01)。治疗后血清及龈沟液中TNF-α、IL-1β与治疗前比较差异有统计学意义(P均<0.01)。结论牙周炎患者对牙周基础治疗有良好的反应性;而TNF-α、IL-1β在牙周炎的发病中均发挥了重要作用,炎症和免疫反应参与了牙周炎疾病的发生与发展。

Objective To investigate the effect of basic treatment on the levels of interleukin-1β （IL-1β） and tumor necrosis factor-α （TNF-α） in the serum and gingival crevicular fluid of patients with aggressive periodontitis. Methods The clinical data of 42 patients with aggressive periodontitis （the study group） admitted to our hospital from February 2011 to May 2012 were retrospectively analyzed and compared with that of healthy people （the control group）. Results Before treatment, the PD, AL, BOP was significantly higher in the study group than the control group （P〈0.01）, and the levels of TNF-α, IL-1β in the serum and gingival crevicular fluid were significantly higher in the study group （P〈0.01）. The PD, AL, BOP after periodontal therapy in the study group were significantly lower than those before treatment （P〈0.01）. The levels of TNF-α, IL-1β after treatment showed no statistically significant differ- ence between the two groups （P〈0.01）. Conclusion Patients with aggressive periodontitis react well to basic treat- ment, and TNF-α and IL-1β play important roles in the pathogenesis of periodontitis, with inflammation and immune response involved in the occurrence and development of periodontitis.