幽门螺杆菌高耐药流行现状及应对策略

Current state of antibiotic resistance to Helicobacter pylori and strategies to deal with that resistance

幽门螺杆菌(Helicobacter pylori,Hp)的抗生素耐药,特别是双重、多重耐药形势已日趋严峻,且其耐药程度和模式存在地域和人群上的差异。随着细菌耐药率的提高,传统的三联疗法已很难以达到理想的根除效果,作为替代治疗方案的各种四联疗法对多重耐药菌株的疗效有限。对于高耐药人群的Hp根除,个体化治疗方案将是最有效的解决途径。

The resistance of Helicobacter pylori to antibiotics, and especially resistance to multiple drugs, is a serious matter. There are regional and population differences in the state of H. pylori resistance and patterns of resistance. The unacceptable performance of conventional triple therapy has been accompanied by a progressive increase in the prevalence of antimicrobial resistance. As alternative treatment options, quadruple therapies have limited effectiveness against multi- drug resistance. Tailored treatment is the most effective therapy for H. pylori eradication in highly resistant populations.