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Ryanodine受体2和肌集钙蛋白2基因突变与儿茶酚胺敏感性多形性室性心动过速 被引量:3

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摘要 钙离子(Ca2+)是人体内一种极其重要的信号分子,其主要功能是参与胞内及胞间信号转导、钙依赖蛋白酶活性的调节等[1]。在心肌细胞中,Ca2+还参与心肌细胞兴奋-收缩偶联(excitation-contraction coupling,ECC)的调控并起重要作用[2]。
出处 《广东医学》 CAS CSCD 北大核心 2013年第8期1297-1299,共3页 Guangdong Medical Journal
基金 国家自然科学基金资助项目(编号:81172901) "十二五"国家科技支撑计划项目(编号:2012BAK02B02) 中央高校基本科研业务费青年教师培育计划项目(编号:11ykpy04)
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参考文献27

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同被引文献18

  • 1Laitinen P J,Brown K M,Piippo K. Mutations of the cardiac ryanodine receptor(RyR2)gene in familial polymorphic ventricular tachycardia[J].CIRCULATION,2001,(04):485-490.
  • 2Marks A R,Priori S,Memmi M. Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia[J].Journal of Cellular Physiology,2002,(01):1-6.
  • 3Lahat H,Pras E,Olender T. A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel[J].American Journal of Hunan Genetics,2001,(06):1378-1384.
  • 4Postma A V,Denjoy I,Hoorntje T M. Absence of calsequestrin 2 causes severe forms of catecholam inergic polymorphic ventricular tachycardia[J].Circulation Research,2002,(08):21-26.
  • 5Priori S G,Napolitano C,M emmi M. Clinical and molecular characterizati0n of patients with catecholaminergic polymorphic ventricular tachycardia[J].CIRCULATION,2002,(01):69-74.
  • 6Paavola J,Viitaslao M,Laitinen-Forsblom PJ. Mutnat rynaodine receptors in catecholaminergic polymorphic ventifcular tachycardia generate delayed afterdepolarizations due to increased propensity to Ca2+ waves[J].EUROPEAN HEART JOURNAL,2007.1135.
  • 7张萍.儿茶酚胺敏感性多形性室性心动过速[J].中华实用诊断与治疗杂志,2010,24(6):528-530. 被引量:4
  • 8郑秀菊,李桂云,孙建霞.儿茶酚胺敏感性室性心动过速2例报告[J].山东医药,2012,52(17):89-90. 被引量:2
  • 9肖幸,柯俊,张存泰,贺莉,肖志超,阮磊.阻断Ryanodine受体对兔儿茶酚胺敏感性室速模型心律失常发生的抑制作用[J].内科急危重症杂志,2012,18(6):370-372. 被引量:2
  • 10洪葵,刘欣,胡大一.2013HRS/EHRA/APHRS遗传性心律失常综合征患者诊断和治疗专家共识解读[J].中华心血管病杂志,2013,41(11):978-981. 被引量:7

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