温针灸对膝骨性关节炎患者血清中IL-17、IL-18表达影响的研究

Effect of Moxibustion with Warming Needling on IL-17 and IL-18 of Knee Osteoarthritis Patients

目的:比较温针灸治疗膝骨性关节炎患者前后血清中IL-17、IL-18水平表达,探讨温针灸治疗膝骨性关节炎的机理。方法:60例KOA患者随机分为温针灸治疗组和药物对照组,每组各30例,收集治疗前后患者血清,用双抗体夹心酶联免疫吸附法检测温针灸治疗KOA患者前后血清中IL-17、IL-18水平。结果:温针灸组在改善患者临床症状方面优于对照组(P<0.05);温针灸治疗后IL-17、IL-18含量显著降低(P<0.05)。结论:IL-17、IL-18参与了KOA的发生发展,说明温针灸治疗KOA的机理与其抑制IL-17、IL-18表达有关。

Objective ：To compare the IL -17 and IL- 18 expressions of knee osteoarthritisbefore and after treatment of moxi- bustion with warming needles,this paper discusses the mechanism of moxibustion with warming needles. Methods：60 cases were randomly divided into KOA moxibustion with warming needles treatment group and drug control group, with 30 cases in each group. Before and after treatment, ouble antibody sandwich enzyme - linked immunosorbent method was used to detect IL - 17 and IL- 18 levels. Results：The moxibustion with warming needles group improved the clinical symptoms better than control group （ P 〈 0. 05 ）. After moxibustion with warming needles, IL - 17 and IL - 18 levels were obviously lower（ P 〈 O. 05 ）. Conclusion ： IL - 17 and IL - 18 participate in the occurrence of KOA and the mechanism of moxibustion with warming needles treating KOA may be associated with inhibiting levels of IL - 17 and IL - 18.