临床T_(1～2)N_0M_0乳腺癌患者腋窝淋巴结转移的高危因素探讨

Study on the Risk Factors of Axillary Lymph Node Metastases in Patients with T_(1～2)N_0M_0 Breast Cancer

目的 :探讨临床T1～ 2 N0 M0 乳腺癌患者腋窝淋巴结转移 (ALNM)的高危因素。方法 :采用回顾性病例对照研究 ,对 2 5 6例乳腺癌患者进行单因素及多因素Logistic回归分析。 结果 :多因素分析显示微淋巴管浸润、肿瘤大小、肿瘤部位、癌周浸润、间质浸润等 5个指标进入Logistic回归方程 ,P值分别为 0、0 .0 0 5 6、0 .0 2 3 9、0 .0 2 2 5和0 .0 30 1。结论 :微淋巴管浸润、肿瘤大小、肿瘤部位、癌周浸润、间质浸润等为临床T1～ 2 N0 M0 乳腺癌患者ALNM的高危因素 ;了解高危因素 ,有助于临床准确判断ALNM情况。

Objective:To investigate the risk factors of axillary lymph node metastases (ALNM) in patients with T 1～2 N 0M 0 breast cancer. Methods: 256 cases of T 1～2 N 0M 0 breast cancer were studied using retrospective analysis, control study, single and multi-factors logistic regression analysis. Results: Multi-factors logistic regression analysis showed that 5 factors including microlymphatic invasion, diameter of primary tumor, location of tumor, circumferential and stromal invasion entered the logistic equation, the p values were 0, 0.0056 , 0.0239 , 0.0225 , 0.0301 respectively. Conclusions: Microlymphatic invasion, diameter of primary tumor, location of tumor, circumferential and stromal invasion were the risk factors of ALNM. Learning the risk factors might be good for clinician to predicate the status of ALNM more exactly.