尿吡啶酚和脱氧吡啶酚在恶性肿瘤骨转移中的临床意义

Clinical Significance of Urinary Pyridinium Cross-links in Neoplastic Bone Disease

目的 :评价尿吡啶酚和脱氧吡啶酚对恶性肿瘤骨转移患者的临床意义。方法 :采用ELISA方法检测了2 6例限局性恶性肿瘤、35例进展期肿瘤骨转移阴性和 34例骨转移阳性的尿吡啶酚和脱氧吡啶酚水平。结果 :进展期肿瘤尿吡啶酚和脱氧吡啶酚水平明显高于限局性肿瘤 (P <0 .0 5 ) ;进展期肿瘤骨转移阳性尿吡啶酚和脱氧吡啶酚水平又明显高于骨转移阴性 (P <0 .0 5 )。结论 :尿吡啶酚和脱氧吡啶酚可以在评价进展期肿瘤骨转移和骨吸收中发挥作用。

Objective:To evaluate the clinical significance of pyridinoline (PYD) and deoxypyridinoline (DPD) in patients with cancer.Medthod:Urine pyridinoline and deoxypyridinline were measured by ELISA assay in 26 patients with local cancer and 69 advanced cancer patients with or without bone metastases.Result:Advanced cancer patients with or without bone metastases had significantly higher urine concentrations of PYD and DPD than those of local cancer patients.The concentrations of both cross-links were also significantly higher in advanced cancer patients with bone metastases than those without bone metastases.Conclusion:These findings suggest that the measurement of PYD and DPD in urine may be useful in assessing bone metastases and bone resorption in cancer patients.