预防诺维本致周围静脉炎的临床研究

Clinical Study of Preventing Phlebitis Caused by NVB

目的 :通过改变NVB的浓度和投药方法 ,降低其所致静脉炎的发生率和严重度。方法 :共 4种给药法1)NVB 40mg +NS 5 0ml,静注 10分钟 ,计 18次 ;2 )NVB 40mg +NS 12 5ml,静滴 2 0分钟 ,计 2 0次 ;3)NVB 40mg +NS 2 5 0ml,静滴 40分钟 ,计 2 0次 ;4)NVB 40mg +NS 12 5ml静滴 2 0分钟 ,前后用氢化考的松 5 0mg +NS 2 5 0ml静滴 ,计 84次。结果 :各组静脉炎发生率分别为 77.8%、80 %、90 %和 2 6 .2 % ;其中Ⅲ度静脉炎分别为 16 .7%、15 %、10 %和 2 .4%。结论 :第 4种方法较前 3种方法静脉炎的发生率和严重度明显下降 (P <0 .0 1) ,也远较国内外报道的 36 .1%～ 8.5 %低 ,推荐临床使用。

Objective: To assess the efficiency of different modes of administration in preventing NVB induced phlebitis. Methods: Administration of NVB has four modes: A: NVB 40mg+NS 50ml IV. in 10 minutes (18 times); B: NVB 40mg+NS 125ml IV. gtt. in 20 minutes (20 times); C: NVB 40mg +NS 250ml IV. gtt. in 40 minutes (20 times); D: NVB 40mg+NS 125ml IV. gtt. in 20 minutes, before and after administration, Hydrocortisone adds into NS 250ml and infused (84 times).Results: The rate of phlebitis in group A was 77.8%, group B 80%, group C 90% and group D 26.2%. The rate of grade Ⅲ phlebitis in group A was 16.7%,group B 15%, group C 10%, group D 2.4% ( P <0.01 between A and D, B and D or C and D). Conclusion: The group D gives better response to prevent phlebitis caused by NVB.