摘要
目的:探讨氧化型低密度脂蛋白(Ox—LDL)对老年脑梗死的作用及影响。方法:对30例老年脑梗死患者进行了血浆Ox-LDL、高密度脂蛋白-C,(HDL—C)、低密度脂蛋白-C,(LDL—C)、Cho、TG、apoA、apoB,血浆内皮素水平测定,同时观察血液流变学指标,并与 23例健康老年人对照。结果:老年脑梗死组血浆 Ox— LDL、内皮素水平明显增高; LDL- C、Cho、TG与对照组比较亦增高;HDL—C降低,血液流变学指标明显异常,而且Ox-LDL的变化与血浆内皮素水平、血液流变学指标呈正相关,与HDL-C、 LDL-C、Cho、TG、apoA、apoB无明显相关性。结论:Ox-LDL导致动脉粥样硬化,促进血浆内皮素分泌,影响血液流变性,引起脑缺血、缺氧促进脑梗死的发生和发展。
Objective: To understand the role and mechanisms of the Ox - LDL on cerebral infarction in aged patiens. Methods: Ox- LDL. HDL - C .LDL - C. Cho. TG. apoA. apoB. ET and hemorheology were measure d in 41 cases with old cerebral infarction, and were compared with that of 26 healthy subjects. Results: The levels of Ox - LDL. ET. LDL - C. Cho. TG were significantly higher in old cerebral infartion group than in control, HDL - C were decreased. the hemorheological indexes exhibited remarkable changes, Ox - LDL was positive correlated between plasma ET and hemorheological indexes, it was no significant relationship between HDL - C .LDL - C .Cho .TG .apoA and apoB. Conclusion: Ox - LDL resulted in atherosclerosis, and made plasma endothelin be secreted, and effected hemorheological, and resulted in ischemia and oxygen deficit of brain that made infarction of brain continue progression.
出处
《现代康复》
CSCD
2000年第7期1036-1037,共2页
Modern Rehabilitation
关键词
氧化型低密度脂蛋白
内皮素
血液流变学
脑梗塞
Ox - LDL
plasma endothelin
hemorheological
cerebral infarction
aged patients