氧化型低密度脂蛋白及脂质代谢对老年脑梗死的影响

Effects of Ox -LDL and Lipid metabolism on cerebral infarction in aged patients

目的：探讨氧化型低密度脂蛋白（Ｏｘ—ＬＤＬ）对老年脑梗死的作用及影响。方法：对３０例老年脑梗死患者进行了血浆Ｏｘ－ＬＤＬ、高密度脂蛋白－Ｃ，（ＨＤＬ—Ｃ）、低密度脂蛋白－Ｃ，（ＬＤＬ—Ｃ）、Ｃｈｏ、ＴＧ、ａｐｏＡ、ａｐｏＢ，血浆内皮素水平测定，同时观察血液流变学指标，并与 ２３例健康老年人对照。结果：老年脑梗死组血浆 Ｏｘ— ＬＤＬ、内皮素水平明显增高； ＬＤＬ－ Ｃ、Ｃｈｏ、ＴＧ与对照组比较亦增高；ＨＤＬ—Ｃ降低，血液流变学指标明显异常，而且Ｏｘ－ＬＤＬ的变化与血浆内皮素水平、血液流变学指标呈正相关，与ＨＤＬ－Ｃ、 ＬＤＬ－Ｃ、Ｃｈｏ、ＴＧ、ａｐｏＡ、ａｐｏＢ无明显相关性。结论：Ｏｘ－ＬＤＬ导致动脉粥样硬化，促进血浆内皮素分泌，影响血液流变性，引起脑缺血、缺氧促进脑梗死的发生和发展。

Objective: To understand the role and mechanisms of the Ox - LDL on cerebral infarction in aged patiens. Methods: Ox- LDL. HDL - C .LDL - C. Cho. TG. apoA. apoB. ET and hemorheology were measure d in 41 cases with old cerebral infarction, and were compared with that of 26 healthy subjects. Results: The levels of Ox - LDL. ET. LDL - C. Cho. TG were significantly higher in old cerebral infartion group than in control, HDL - C were decreased. the hemorheological indexes exhibited remarkable changes, Ox - LDL was positive correlated between plasma ET and hemorheological indexes, it was no significant relationship between HDL - C .LDL - C .Cho .TG .apoA and apoB. Conclusion: Ox - LDL resulted in atherosclerosis, and made plasma endothelin be secreted, and effected hemorheological, and resulted in ischemia and oxygen deficit of brain that made infarction of brain continue progression.