非小细胞肺癌bFGF表达与微血管密度的意义

The expression of bFGF and microvessel density in non small cell lung cancer

目的 :探讨非小细胞肺癌 (NSCLC)组织中碱性成纤维细胞生长因子 (bFGF)表达和微血管密度 (MVD)的意义。方法 :采用免疫组化ABC法检测 78例NSCLC标本中bFGF表达和MVD ,并根据病理类型、组织学分化程度、有无区域淋巴结转移以及预后进行分析。结果 :在NSCLC中腺癌的bFGF表达阳性率和MVD值显著高于鳞癌(P <0 0 5 ) ;所有NSCLC病例中 ,bFGF表达阳性率与肿瘤组织学分化程度有关 ,低分化癌bFGF表达阳性率显著高于中、高分化癌 (P <0 0 5 ) ,但MVD值与分化程度的关系不如bFGF明显 ;区域淋巴结转移阳性组NSCLCbFGF表达阳性率和MVD值显著高于阴性组 (P <0 0 5 ) ,而手术后 3年内发生远处转移或死亡的病例 ,其bFGF表达阳性率和MVD值亦明显高于术后 3年内未发生远处转移者 (P <0 0 5 )。结论 :bFGF表达和MVD与NSCLC一些临床病理特征有关 。

Purpose:To investigate the relationship between the expression of basic fibroblast growth factor (bFGF), microvessel density (MVD) and the clinical pathology of non small cell lung cancer (NSCLC).Methods:The expression of bFGF and MVD were observed in 78 cases of NSCLC with immunohistochemical detection. Results:The expression of bFGF and MVD was greater in adenocarcinomas than in squamous cell carcinomas of NSCLC( P <0 05). The expression of bFGF was significantly different among the three groups of both squamous cell carcinomas and adenocarcinomas with varying differentiation ( P <0 05). There was higher bFGF expression and greater MVD in NSCLC patients with regional lymphnode involvement and those with later distant metastasis ( P <0 05) Conclusions:It suggested that the expression of bFGF and MVD is helpful in predicting the risk for metastasis and prognosis in NSCLC