E-cadherin在甲状腺乳头状腺癌中的表达及临床意义

Expression of E-cadherin in papillary thyroid carcinoma and its chlinical significance

目的 :研究E cadherin在甲状腺乳头状腺癌中的表达 ,并探讨其能否成为甲状腺乳头状腺癌独立的预后因素。方法 :应用免疫组化方法 ,对 40例甲状腺乳头状腺癌、10例甲状腺滤泡型腺瘤和 10例甲状腺正常组织进行了E cadherin表达的研究 ,并对可能影响甲状腺癌病人预后的有关因素进行了时序检验单因素生存分析。结果 :9例 (2 2 5 % )甲状腺乳头状腺癌E cadherin表达阳性 ,余多数呈不表达或弱阳性表达 ,2 0例良性对照均为阳性表达 ,差异有显著性 (P <0 0 5 ) ,17例有淋巴结转移的肿瘤其阳性表达率 (5 9% )明显低于无淋巴结转移的阳性表达率(34 78% ) ,(P <0 0 5 )。经时序检验E cadherin与甲状腺乳头状腺癌病人的预后并未表现出明显的相关关系。结论 :在大多数甲状腺乳头状腺癌中上皮细胞表面的E cadherin有一定的破坏 ,其淋巴结转移的发生与E

Purpose:To study the overexpressions of E cadherin and to evaluate whether it can be an independent prognostic factor for patients with papillary thyroid carcinoma. Methods:E cadherin was measured in papillary thyroid carcinomas ( n =40), normal thyroid tissues (n=10),follicular thyroid adenomas(n=10) by immunohistochemical staining. Statistical analysis was based on the Chi squard test and log rank test. Results:We found overexpression of E cadherin in 9 cases (22.5%) among 40 papillary thyroid carcinomas, and E cadherin expression was reduced in the rest of them. Only 1 case had positive expression of E cadherin in the 17 cases with lymph node metastasis. The log rank test for overall survival suggests that E cadherin was not an independent prognostic factor for papillary thyroid carcinoma. Conclusions:E cadherin expression in papillary thyroid carcinoma was reduced, and it was significantly correlated with lymph node metastasis.