丹红注射液对急性脑梗死患者sCD40L及超敏C-反应蛋白的影响

Efficacy of Danhong injection for patients with acute stage of cerebral infarction and its effects on serum sCD40L and hs-CRP levels

目的探讨步长丹红注射液对急性脑梗死患者血清可溶性白细胞分化抗原.40配体(sCD40 L)及超敏C-反应蛋白(hs-CRP)的影响及临床疗效。方法 92例急性脑梗死患者分为两组,即常规治疗组和丹红治疗组,丹红治疗组在常规治疗基础上给予步长丹红注射液30ml溶于0.9%氯化钠注射液250ml,1次/d,静脉滴注,共14d。治疗前后测定血sCD40L及hs-CRP的变化,并用中国卒中量表(CSS)及巴氏指数(BI)评定。结果两组患者sCD40L及hs-CRP均下降,丹红治疗组均明显低于常规治疗组(均P<0.05)。治疗后两组CSS及BI评分较治疗前均明显增加,丹红治疗组均高于常规治疗组(均P<0.05)。结论步长丹红注射液可降低急性脑梗死患者sCD40L及hs-CRP的水平,有益于患者神经功能的恢复。

Objective To evaluate efficacy of Danhong injection for patients with acute stage of cerebral infarction and its effects on serum levels of soluble CD40 ligand （sCD40L） and high-sensitivity C-reactive protein（hs-CRP）. Methods Ninety two patients with acute ischemic cerebral infarction were randomly assigned to receive Danhong injection （30ml/d, i.v drip, for 14d） in addition to routine treatment （Danhong group） or routine treatment only（control group）.Serum sCD40L and hs-CRP were mea-sured, and Barthel index （BI） and Chinese stroke Scale （CSS） were assessed before and after treatment in both groups. Results The levels of sCD40L and hs-CRP were deceased after treatment in both groups, however, the levels in Danhong group were significantly lower than those in control group （P〈0.05）. The scores of CSS and BI of two groups were improved after treatment, while scores in Danhong group were better than those in control group （P〈0.05）. Conclusion Danhong injection can decrease serum levels of sCD40L and hs-CRP and improve the recovery of neural function for patients with acute cerebral infarction.