以头部肿物为突出表现的儿童急性巨核细胞性白血病1例

Head mass as prominent manifestation in a case of pediatric acute megakaryocytic leukemia

患儿,男,1岁4个月,主因发现血小板减少10个月余,头颅肿物进行性肿大4个月余于2011年1月6日入住我科。既往因先心病于2010年3月2日行＂室间隔缺损修补＋房间隔缺损修补＋动脉导管结扎术＂,术中发现血小板中度减少,当时考虑抗凝剂药物不良反应所致,未予重视,之后监测血常规血小板波动于（）9/,仍未重视。

In this case head cele was the outstanding clinical manifestation. Head CT images showed slightly high density shadow in the subcutaneous fat of bilateral frontal and temporal departments. The patient initially suf fered from thrombocytopenia. Then white blood cells gradually increased and mild anemia occurred. Possible leuke mia cell infiltration was found in both bone marrow aspiration and fine needle aspiration of right frontal and tempo ral cele. Immunophenotyping of peripheral blood cells showed：CD61＋ 43.5%,CD41＋ 36.5%,CD13- 37.2% and CD33＋ 41.2 %. The patient was diagnosed as acute megakaryocyte leukemia.