MDSC的功能研究进展与应用前景

Research advancements and application prospect of myeloid-derived suppressor cells

髓源性抑制细胞（myeloid-derived suppressorcells,MDSC）是近年广泛研究的具有免疫抑制功能的细胞群,其来源于骨髓祖细胞和未成熟髓系细胞,在肿瘤、感染、自身免疫性疾病中呈现募集活化,参与免疫逃逸、免疫耐受、炎性反应等病理过程。因此,作为重要的免疫负调控细胞群体,MD-SC在多种疾病中的作用正日益受到关注,

Myeloid-derived suppressor cells（MDSC） originate from the immature myeloid cells in bone mar row. MDSC act as a heterogeneie immunoregulatory population which can expand in response to many pathologica conditions. MDSC can aggravate the development and growth of tumor. Hence, MDSC may become novel therapeu tic targets of many diseases.